Wednesday, 29th November ESA-SRB 2023 in conjunction with ENSA

Presenter: Professor Roger Chen
Garvan, St Vincent’s Hospital, University of Sydney

This talk will cover:

• The evolution of the understanding of Type 2 diabetes

• The role of the gastrointestinal tract (Gut)

• The role of the gut derived hormones

• GIP- Glucose-dependent insulinotropic polypeptide

Topics covered:        

• GIP is a potent incretin hormone in animals.

• GIP knockout mice are protected from weight gain.

• In acute high dose GIP experiments- there is little effect in Type 2 diabetes in humans with regards to glucose lowering

• GIP resistance in Type 2 in clamp studies

• Mice, dogs and humans may all be different.

• Higher affinity agonists with slower elimination PK are now available.

Breakfast is included.

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