Poster Presentation ESA-SRB 2023 in conjunction with ENSA

Fracture risk in Breast Cancer Bone Metastases: Does Obesity have an effect? (#232)

Michelle Maugham-Macan 1 , Huong Duong 1
  1. University of the Sunshine Coast, Sippy Downs, QLD, Australia

Obesity is now recognised as a key risk factor for cancer with Breast Cancer one of thirteen obesity-driven cancers identified by the World Cancer Research Fund. Breast Cancer bone metastasis is a debilitating disease and recent research has demonstrated a link between obesity and poorer outcomes from bone metastatic breast cancer. The aim of this study is to investigate the impact of obesity on breast cancer bone metastases outcomes, specifically fracture risk and overall survival. We conducted a scoping review of existing literature to investigate the effect of obesity on fracture risk in bone metastatic breast cancer. At the time of review there was no literature examining this association. We therefore are conducting a retrospective analysis of female patients diagnosed with breast cancer bone metastases reviewed by a multidisciplinary team on the Sunshine Coast between 2008 and 2021. Patient BMI, evidence of fractures during the study period and survival 5 years and 10 years after diagnosis are manually extracted from CHARM Oncology database. Anonymised data will then undergo correlation analysis. We hypothesise that there is a correlation between body mass index and fracture risk as well as overall survival. The results of this study along with results of our scoping review will support future research into strategies that may reduce the impact of breast cancer bone metastases such as exercise physiologist-prescribed, personalised exercise plans to manage obesity and reduce bone loss that occurs with osteolytic lesions of bone metastatic breast cancer and therefore decrease bone pain and fracture risk and increase quality of life.