The endometrial lining, constituting the internal layer of the uterus, is central to reproductive health due to its essential role in supporting mammalian life. One of the most notable features of the endometrium is its remarkable ability to regenerate, a mechanism vital for reproductive success and overall health. However, the foundations of its renewal and the negative effects of its malfunctions, especially in relation to aging and reproductive pathologies in females, continue to be areas of significant interest and scrutiny. The multifaceted intricacies guiding these endometrial functions and the potential pitfalls when disrupted have been the cornerstone of my investigations. Our body of work illuminates the intricate endometrial environment, mapping from stem cell behaviour to the changes brought on by ageing. Integrating our knowledge of stem cell dynamics, notably guided by Wnt signalling pathways, with findings on age-related alterations and their ensuing consequences, we provide an encompassing overview. This integrated knowledge aims to refine and improve methods for diagnosing, preventing, and treating endometrial cancers and associated reproductive issues.