INTRODUCTION
Dilated cardiomyopathy(DCM) is one of the deadliest complication in patients with hyperthyroidism and is the major cause of mortality.We intended to study the incidence of DCM and its recovery pattern in hyperthyroid patients.
MATERIALS AND METHODS
Three ninety one patients (age< 60 years )with newly diagnosed hyperthyroidism were evaluated with 2D Echocardiography, at the time of diagnosis(Point A),after achieving euthyroidism(Point B) with anti-thyroid drugs and 6 months after achieving euthyroidism (Point C).60 patients (age< 60 years) with nontoxic benign thyroid nodules served as controls.
RESULTS
At point A, DCM was evident in 50/391(12.7%).cardiac failure was observed in 18/391(4.6%).28/50 patients improved completely at Point B with all other cohorts showing a significant improvement in the cardiac indices. cardiac failure improved all patients at point B.At Point C dramatic improvement in DCM occurred in 41/50(82%) with remaining 9 patients also showing a significant improvement .
CONCLUSION
DCM is one of the dreaded complication of hyperthyroid cardiac dysfunction and if diagnosed early and treated properly mortality and morbidity can be prevented .
TABLE 1
IVS-Interventricular septum
|
Variables |
Group 1 |
Group 2 |
p value |
|
LV End diastolic dimension(mm) |
40.72±4.07 |
41.95±5.21 |
.002 |
|
LV End systolic dimension (mm) |
26.11±3.06 |
28.18±4.1 |
.01 |
|
LV End diastolic volume (ml) |
68.86±12.07 |
75.09±9.41 |
.03 |
|
LV End systolic volume (ml) |
31.09±7.34 |
33.12±6.73 |
.04 |
|
LV ejection fraction |
64.08±4.11 |
61.54±3.83 |
.01 |
|
IVS diastolic thickness |
9.09±1.06 |
9.9±1.51 |
.14 |
|
Posterior wall thickness |
9.14±1.7 |
9.38±1.4 |
.57 |
|
pulmonary hypertension |
23.05±2.3 |
24.08±2.35 |
.07 |
LV-left ventricle